5-甲基-3-苯基-4,5-二氢-异噁唑-5-羧酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran 4 h; 2: With hydrogenchloride in water
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2005/21516 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;
WO 2005/021516 A1
反应条件
lithium hydroxide in tetrahydrofuran; methanol; water T=20°C; 2 h;
参考文献
WO2006/90234 A1, ;
Page/Page column 33-34 ;
反应条件
1: sodium hypochlorite / tetrahydrofuran / 20 °C 2: lithium hydroxide hydrate; water / tetrahydrofuran; methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 5 p. 1482 - 1485
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 °C 2: sodium hypochlorite / tetrahydrofuran / 20 °C 3: lithium hydroxide hydrate; water / tetrahydrofuran; methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 5 p. 1482 - 1485
