(-)-N-[1-(R)-乙氧基碳二甲基苯基-3-苯基丙基]-L-丙氨酸合成路线 （共 12 条）
反应条件
sulfuric acid; hydrogen; palladium on activated charcoal in acetic acid T=25 - 30°C; P=760 Torr;
参考文献
Urbach, H.; Henning, R.
Tetrahedron Letters, 1984 , vol. 25, # 11 p. 1143 - 1146
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 25, # 11 p. 1143 - 1146
反应条件
1: N(C2H5)3 / ethanol / Ambient temperature 2: 74 percent / H2, cc.H2SO4 / Pd/C / acetic acid / 25 - 30 °C / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 11 p. 1143 - 1146
反应条件
1: 84 percent / pyridine / CH2Cl2 / 0 °C 2: N(C2H5)3 / CH2Cl2 / Ambient temperature 3: H2 / Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 11 p. 1143 - 1146
反应条件
1: N(C2H5)3 / CH2Cl2 / Ambient temperature 2: H2 / Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 11 p. 1143 - 1146
反应条件
1: 45 percent / methanol; H2O / 8 h / 70 °C 2: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 3: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 4: 95 percent / SOCl2 / 24 h / Ambient temperature 5: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 6: CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 2: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 3: 95 percent / SOCl2 / 24 h / Ambient temperature 4: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 5: CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: 95 percent / SOCl2 / 24 h / Ambient temperature 2: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 3: CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 2: CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 2: 95 percent / SOCl2 / 24 h / Ambient temperature 3: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 4: CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
