6-氯-4-甲氧基烟酸甲酯合成路线 （共 7 条）
反应条件
in tetrahydrofuran T=20°C; 18 h; Inert atmosphere;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; COLLINS, Ian; LAINCHBURY, Michael; MATTHEWS, Thomas Peter; READER, John Charles
Patent: WO2013/68755 A1, 2013 ;
Location in patent: Page/Page column 71 ;
反应条件
tert-butyl alcohol in hexane T=0 - 20°C; Inert atmosphere;
参考文献
PFIZER INC.; ARHANCET, Graciela Barbieri; CASIMIRO-GARCIA, Agustin; CHEN, Xiangyang; HEPWORTH, David; MEYERS, Marvin Jay; PIOTROWSKI, David Walter; RAHEJA, Raj Kumar
Patent: WO2010/116282 A1, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/116282 A1
反应条件
sodium ethanolate in tetrahydrofuran; methanol T=0 - 20°C;
参考文献
EP2085383 A1, ;
Page/Page column 26 ;
EP 2085383 A1
反应条件
1.1: acetic anhydride / 2 h / 130 °C 1.2: 1 h / 0 °C 1.3: 0.33 h / 20 °C 2.1: N,N-diethylaniline; trichlorophosphate / 21 h / 20 °C / Reflux 3.1: methanol / 3 h / 0 - 20 °C View Scheme
参考文献
WO2012/110860 A1, ;
WO 2012/110860 A1
反应条件
1: N,N-diethylaniline; trichlorophosphate / 21 h / 20 °C / Reflux 2: methanol / 3 h / 0 - 20 °C View Scheme
参考文献
WO2012/110860 A1, ;
WO 2012/110860 A1
反应条件
lithium hydroxide hydrate in tetrahydrofuran T=20°C; 3 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; GAJERA, Jitendra Maganbhai; NARAYANA, Lakshminarayana; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2012/110860 A1, 2012 ;
Location in patent: Page/Page column 99 ;
WO 2012/110860 A1
反应条件
1: 33 percent / H2O / 12 h / Ambient temperature
2: 45 percent / 1.) liquid NH3, Na, Fe(NO3)3; 2.) NH4Cl / 1.) 1 h, dioxane; 2.) 1 h, reflux; 2 h, room temp.
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
