pyridine in water

in pyridine 75 h; Heating;

1: 0 °C 2: triethylamine, ethyl chloroformate / CHCl3 / 3.5 h / Ambient temperature 3: 1.) sodium hydride / 1.) THF, RT, 1 h, 2.) THF, RT, 1 h 4: dimethylformamide / 2 h / Ambient temperature 5: diphenyl ether / 0.2 h / 250 °C 6: 84 percent / trifluoromethanesulfonic acid, trifluoroacetic acid, anisole / 2 h / Ambient temperature 7: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min. 8: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 9: 52 percent / pyridine / 75 h / Heating View Scheme

1: 1.) sodium hydride / 1.) THF, RT, 1 h, 2.) THF, RT, 1 h 2: dimethylformamide / 2 h / Ambient temperature 3: diphenyl ether / 0.2 h / 250 °C 4: 84 percent / trifluoromethanesulfonic acid, trifluoroacetic acid, anisole / 2 h / Ambient temperature 5: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min. 6: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 7: 52 percent / pyridine / 75 h / Heating View Scheme

1: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min. 2: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 3: 52 percent / pyridine / 75 h / Heating View Scheme

1: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 2: 52 percent / pyridine / 75 h / Heating View Scheme

1: 84 percent / trifluoromethanesulfonic acid, trifluoroacetic acid, anisole / 2 h / Ambient temperature 2: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min. 3: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 4: 52 percent / pyridine / 75 h / Heating View Scheme

1: diphenyl ether / 0.2 h / 250 °C 2: 84 percent / trifluoromethanesulfonic acid, trifluoroacetic acid, anisole / 2 h / Ambient temperature 3: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min. 4: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 5: 52 percent / pyridine / 75 h / Heating View Scheme

1: dimethylformamide / 2 h / Ambient temperature 2: diphenyl ether / 0.2 h / 250 °C 3: 84 percent / trifluoromethanesulfonic acid, trifluoroacetic acid, anisole / 2 h / Ambient temperature 4: 1.) potassium bicarbonate / 1.) DMF, 80 deg, 12 h, 2.) conc. sulfuric acid, 90 deg, 20 min. 5: 73 percent / sodium hydroxide, water / ethanol / 2 h / Heating 6: 52 percent / pyridine / 75 h / Heating View Scheme