1: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C 2: 84 percent / dimethylformamide / Ambient temperature 3: 88 percent / KOH / 2-methyl-propan-2-ol; H2O / 1 h / 50 - 60 °C View Scheme

potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=105 - 110°C; 0.5 h;

1: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C 2: 84 percent / dimethylformamide / Ambient temperature 3: 88 percent / KOH / 2-methyl-propan-2-ol; H2O / 1 h / 50 - 60 °C 4: 62 percent / KHCO3 / dimethylformamide / 5 h / Ambient temperature View Scheme

1: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C 2: 84 percent / dimethylformamide / Ambient temperature View Scheme

1: 1.) sodium / 1.) ethanol, 0 deg C, 1,5 h, 2.) ethanol, RT, 3,5 h 2: 89 percent / conc. sulfuric acid / 1 h / 0 °C 3: sodium hydroxide, water / ethanol / 2 h / Heating 4: 73 percent / pyridine / 2 h / 100 °C View Scheme

1: 1.) sodium / 1.) ethanol, 0 deg C, 1,5 h, 2.) ethanol, RT, 3,5 h 2: 89 percent / conc. sulfuric acid / 1 h / 0 °C 3: sodium hydroxide, water / ethanol / 2 h / Heating 4: 73 percent / pyridine / 2 h / 100 °C View Scheme