N-Boc-4-氧代-脯氨酸合成路线 （共 23 条）
反应条件
chromic acid in water; acetone T=25°C; 0.75 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/5249 A1, 2004 ;
Location in patent: Page 30-31 ;
WO 2004/005249 A1
反应条件
chromic acid in water; acetone
参考文献
Halazy, Serge; Quattropani, Anna; Scheer, Alexander; Schwarz, Mattias; Thomas, Russell; Baxter, Antony
Patent: US2003/212012 A1, 2003 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 24 h;
参考文献
Barraclough, Paul; Hudhomme, Pietrick; Spray, Caroline A.; Young, Douglas W.
Tetrahedron, 1995 , vol. 51, # 14 p. 4195 - 4212
反应条件
3'-phenoxy-4'-fluoro-α'-cyanobenzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropane-carboxylate in isopropanol acetate
反应条件
triethanolamine in hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate
反应条件
1: Na2CO3 2: 49 percent / CrO3; pyridine / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 10 p. 3593 - 3596
反应条件
1: Na2CO3 2: 49 percent / CrO3; pyridine / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 10 p. 3593 - 3596
反应条件
pyridine; chromium(VI) oxide 1.) CH2Cl2, 0 deg C, 5 min; 2.) CHCl2, 4 h, r.t.; Yield given. Multistep reaction;
参考文献
Canadian Journal of Chemistry, , vol. 60, # 23 p. 2903 - 2907
反应条件
1: 90 percent / sodium borohydride / methanol / 3.5 h / 0 °C 2: 62 percent / aq. NaOH / diethyl ether / 24 h 3: 36 percent / lithium triethylborodeuteride / tetrahydrofuran / 24 h / Heating 4: trifluoroacetic acid / 0.5 h 5: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 2 h; 2: (2S)-4-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester in tetrahydrofuran T=0 - 20°C;
参考文献
ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; PENG, Xiaowen; KIM, In, Jong; CAO, Hui; TANG, Datong; OR, Yat, Sun; WANG, Guoqiang; XU, Guoyou
Patent: WO2012/158861 A2, 2012 ;
Location in patent: Page/Page column 19-20 ;
