N-Boc-4-氧代-脯氨酸合成路线 （共 23 条）
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane 3 h; Ambient temperature;
参考文献
Barraclough, Paul; Hudhomme, Pietrick; Spray, Caroline A.; Young, Douglas W.
Tetrahedron, 1995 , vol. 51, # 14 p. 4195 - 4212
反应条件
1.1: sodium tetrahydroborate / methanol; water / 0.42 h / 0 - 4 °C 1.2: pH 3 2.1: methanol; diethyl ether 3.1: triethylamine / dichloromethane / 0.5 h / 0 °C 4.1: sodium azide / N,N-dimethyl-formamide / 55 °C View Scheme
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1: 90 percent / sodium borohydride / methanol / 3.5 h / 0 °C
2: 62 percent / aq. NaOH / diethyl ether / 24 h
3: 36 percent / lithium triethylborodeuteride / tetrahydrofuran / 24 h / Heating
4: trifluoroacetic acid / 0.5 h
5: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation
6: 85 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h
7: 66 percent / aq. NaOH / diethyl ether / 24 h
View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
