(S)-1-(叔丁氧基羰基)-2-甲基-4-亚甲基吡咯烷-2-羧酸合成路线 （共 23 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=25°C; 3 h;
参考文献
Manfre; Kern; Biellmann
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2060 - 2065
反应条件
1.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere 1.2: 72 h / -5 - 30 °C / Inert atmosphere 1.3: 24 h / 20 °C 2.1: water; sodium hydroxide / ethanol / 24 h View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 30 p. 3847 - 3849
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran
T=-20 - -5°C; 0.5 h;
2: N-Boc-4-oxo-L-proline methyl ester in tetrahydrofuran
T=20°C; 3 h;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
Location in patent: Paragraph 00660 ;
反应条件
potassium carbonate; N,N-dimethyl-formamide
T=20°C; 7 h;
参考文献
ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; PENG, Xiaowen; KIM, In, Jong; CAO, Hui; TANG, Datong; OR, Yat, Sun; WANG, Guoqiang; XU, Guoyou
Patent: WO2012/158861 A2, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
bis(cyclopentadienyl)titanium dichloride in tetrahydrofuran; toluene
T=-78 - 20°C; 26 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tymtsunik, Andriy V.; Bilenko, Vitaliy A.; Ivon, Yevhen M.; Grygorenko, Oleksandr O.; Komarov, Igor V.
Tetrahedron Letters, 2012 , vol. 53, # 30 p. 3847 - 3849
反应条件
methylidene triphenyl phosphorane in tetrahydrofuran; toluene
T=-20 - 20°C; 3.08333 h;
参考文献
Zhuo, Jincong; Li, Yun-Long; Xu, Meizhong; He, Chunhong; Yao, Wenqing
Patent: US2007/208001 A1, 2007 ;
Location in patent: Page/Page column 35 ;
US 20070208001 A1
反应条件
diethylzinc in n-heptane; dichloromethane
T=-5 - 20°C; 19.5 h; Overall yield = 62 percent; Overall yield = 46.6 g;
参考文献
Gilead Sciences, Inc.; Scott, Robert William; Vitale, Justin Philip; Matthews, Kenneth Stanley; Teresk, Martin Gerald; Formella, Alexandra; Evans, Jared Wayne
Patent: US2013/324740 A1, 2013 ;
Location in patent: Paragraph 0131; 0132; 0133 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
SPIROGEN LIMITED
Patent: US2011/256157 A1, 2011 ;
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
Sanofi-Aventis
Patent: EP1813614 A1, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
potassium tert-butylate in diethyl ether
参考文献
Halazy, Serge; Quattropani, Anna; Scheer, Alexander; Schwarz, Mattias; Thomas, Russell; Baxter, Antony
Patent: US2003/212012 A1, 2003 ;
