(S)-1-(叔丁氧基羰基)-2-甲基-4-亚甲基吡咯烷-2-羧酸合成路线 （共 23 条）
反应条件
1: diiodomethane With diethylzinc; trifluoroacetic acid in hexane; dichloromethane
T=-5°C; Simmons-Smith reaction; 1 h; Inert atmosphere;
2: (2S)-methyl N-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylate in hexane; dichloromethane
T=-5 - 30°C; Simmons-Smith reaction; 72 h; Inert atmosphere;
参考文献
Tymtsunik, Andriy V.; Bilenko, Vitaliy A.; Ivon, Yevhen M.; Grygorenko, Oleksandr O.; Komarov, Igor V.
Tetrahedron Letters, 2012 , vol. 53, # 30 p. 3847 - 3849
反应条件
1: tetrabutylammomium bromide / 1,2-dichloro-ethane / 3.17 h / 70 °C / Inert atmosphere
2: 2,2'-azo-bisisobutyronitrile; tris-(trimethylsilyl)silane / toluene / 24 h / 0 - 90 °C
View Scheme
参考文献
ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; PENG, Xiaowen; KIM, In, Jong; CAO, Hui; TANG, Datong; OR, Yat, Sun; WANG, Guoqiang; XU, Guoyou
Patent: WO2012/158861 A2, 2012 ;
反应条件
triethylamine; trifluoroacetic acid in dichloromethane
0.5 h;
参考文献
Shi, Wei; Ma, Haikun; Duan, Yuejiao; Aubart, Kelly; Fang, Yuhong; Zonis, Rimma; Yang, Liping; Hu, Wenhao
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1060 - 1063
