1: With n-butyllithium in tetrahydrofuran; hexane; toluene T=-75 - -74°C; 2.25 h; 2: With hydrogenchloride; water in tetrahydrofuran; hexane; toluene T=-20 - 20°C; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/87488 A2, 2007 ;
Location in patent: Page/Page column 17; 47-48 ;