(5alpha,10alpha,17beta)-5,10-环氧-17-羟基-17-(1-丙炔-1-基)-雌甾-9(11)-烯-3-酮环1,2-乙二基缩醛合成路线 （共 6 条）
反应条件
1: in tetrahydrofuran
T=0°C; 2 h;
2: With ammonium chloride in water
参考文献
ABBOTT LABORATORIES
Patent: WO2004/869 A1, 2003 ;
Location in patent: Page 23 ;
WO 2004/000869 A1
反应条件
1: in tetrahydrofuran
T=0°C; 2.5 h;
2: With ammonium chloride in tetrahydrofuran; water
参考文献
ABBOTT LABORATORIES
Patent: WO2004/869 A1, 2003 ;
Location in patent: Page 36 ;
WO 2004/000869 A1
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
参考文献
Jiang, Weiqin; Fiordeliso, James J.; Allan, George; Linton, Olivia; Tannenbaum, Pamela; Xu, Jun; Zhu, Peifang; Gunnet, Joseph; Demarest, Keith; Lundeen, Scott; Sui, Zhihua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1471 - 1474
反应条件
1: 85 percent / tetrahydrofuran
2: 35 percent / m-CPBA / CH2Cl2
View Scheme
参考文献
Jiang, Weiqin; Fiordeliso, James J.; Allan, George; Linton, Olivia; Tannenbaum, Pamela; Xu, Jun; Zhu, Peifang; Gunnet, Joseph; Demarest, Keith; Lundeen, Scott; Sui, Zhihua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1471 - 1474
反应条件
pyridine; 1,1,1,3,3,3-hexachloro-propan-2-one; Br(1-)*C26H29N2O(1+); dihydrogen peroxide in dichloromethane; water
T=20°C; 48 h; optical yield given as percent dediastereoselective reaction;
参考文献
Yang, Ya-Xi; Li, Zheng; Chen, Guo-Rong; Li, Yuan-Chao
Letters in Organic Chemistry, 2010 , vol. 7, # 2 p. 163 - 167
反应条件
in tetrahydrofuran; hexane
1 h; Yield given;
参考文献
Mais; Chen; Wagoner; Scott Hayes; Wang
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 12 p. 1199 - 1203
