反应条件
1: 1) Et3N, ethyl chloroformate, 2) NH3 / 1) CH2Cl2, 15 to 20 deg C, 1 h 2: 70 percent / pyridine, trifluoroacetic anhydride / dioxane / 16 h / 20 °C 3: NH2OH*HCl, K2CO3 / ethanol; H2O / 1 h / Heating 4: 160 °C View Scheme
参考文献
Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291
