1: 91 percent / HCl (2N) / tetrahydrofuran / 3 h / Ambient temperature 2: Pb(OAc)4 / benzene / 2 h / Ambient temperature 3: NaBH4 / methanol; tetrahydrofuran / Ambient temperature 4: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 5: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 6: 95 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr 7: 93 percent / pyridine / 2 h / 70 °C View Scheme

1: 91 percent / 1N HCl / Ambient temperature View Scheme

1: 87 percent / H2 / palladium black / methanol; acetic acid / 760 Torr / Ambient temperature 2: 1.) KH / 1.) benzene, room temp.; 2.) room temp., 2 h 3: 98 percent / HCl (6N) / tetrahydrofuran / 0.08 h / Ambient temperature 4: 1.) Pb(OAc)4; 2.) NaBH4 / 1.) benzene, room temp.; 2.) MeOH, THF, room temp. 5: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h View Scheme

1: 91 percent / HCl (2N) / tetrahydrofuran / 3 h / Ambient temperature 2: Pb(OAc)4 / benzene / 2 h / Ambient temperature 3: NaBH4 / methanol; tetrahydrofuran / Ambient temperature 4: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h View Scheme

1: 87 percent / H2 / palladium black / methanol; acetic acid / 760 Torr / Ambient temperature 2: 1.) KH / 1.) benzene, room temp.; 2.) room temp., 2 h 3: 98 percent / HCl (6N) / tetrahydrofuran / 0.08 h / Ambient temperature 4: 1.) Pb(OAc)4; 2.) NaBH4 / 1.) benzene, room temp.; 2.) MeOH, THF, room temp. View Scheme