4,7,8,9-四-氧-乙酰基-N-神经氨酸甲酯合成路线 （共 12 条）
反应条件
perchloric acid T=40°C; 2.5 h;
参考文献
Baggett; Marsden
Carbohydrate research, 1982 , vol. 110, # 1 p. 11 - 18
反应条件
1: 90 percent / conc. HCl, AcCl / CH2Cl2 / 72 h 2: 87 percent / Ag2CO3 / acetone; H2O / 72 h View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 11109 - 11120
反应条件
Ag2CO3; water in acetone T=20°C; 0.5 h; Inert atmosphere;
参考文献
Wolf, Saskia; Warnecke, Svenja; Ehrit, Joerg; Freiberger, Friedrich; Gerardy-Schahn, Rita; Meier, Chris
ChemBioChem, 2012 , vol. 13, # 17 p. 2605 - 2615
反应条件
silver carbonate in water; acetone 72 h;
参考文献
Chappell, Mark D.; Halcomb, Randall L.
Tetrahedron, 1997 , vol. 53, # 32 p. 11109 - 11120
反应条件
1.1: pyridine / 2 h / 20 °C 2.1: cesium carbonate / methanol 2.2: dimethylformamide / 24 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 19 p. 6145 - 6152
反应条件
1: (2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-hydroxy-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid With caesium carbonate in methanol Addition; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; Methylation; 24 h; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 65, # 19 p. 6145 - 6152
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium thioacyanate in dichloromethane 0.5 h; Heating;
参考文献
Liebigs Annalen der Chemie, , # 8 p. 799 - 802
反应条件
1: Dowex 50W * 8 (H+) 2: HClO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 22 p. 8748 - 8750
反应条件
N-benzyl-N,N,N-triethylammonium chloride in dichloromethane 0.5 h; Heating;
参考文献
Liebigs Annalen der Chemie, , # 8 p. 799 - 802
反应条件
T=0 - 20°C; 16 h; Inert atmosphere;
参考文献
ChemBioChem, , vol. 13, # 17 p. 2605 - 2615
