2-[4-(三氟甲基)苯基]苯甲醛合成路线 （共 9 条）
反应条件
palladium diacetate; triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; isopropylamine in water; acetonitrile T=80°C; Suzuki cross-coupling; 4 h;
参考文献
Dupuis, Christophe; Adiey, Kouacou; Charruault, Lise; Michelet, Veronique; Savignac, Monique; Genet, Jean-Pierre
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6523 - 6526
反应条件
1: 4-trifluoromethylphenylbromobenzene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C;
参考文献
Varela, Jesus A.; Pena, Diego; Goldfuss, Bernd; Denisenko, Dmitri; Kulhanek, Jiri; Polborn, Kurt; Knochel, Paul
Chemistry - A European Journal, 2004 , vol. 10, # 17 p. 4252 - 4264
反应条件
bis(tri-o-tolylphosphine)palladium acetate in methanol T=20°C; 0.0833333 h;
参考文献
Dupuis, Christophe; Adiey, Kouacou; Charruault, Lise; Michelet, Veronique; Savignac, Monique; Genet, Jean-Pierre
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6523 - 6526
反应条件
phenone oxime-derived palladacycle; tetrabutylammomium bromide; potassium carbonate in water Suzuki coupling; 9 h; Heating;
参考文献
Botella, Luis; Najera, Carmen
Journal of Organometallic Chemistry, 2002 , vol. 663, # 1-2 p. 46 - 57
反应条件
1.1: tBuLi / tetrahydrofuran / 1 h / -78 °C 1.2: ZnBr2 / tetrahydrofuran / 0.5 h / 20 °C 1.3: 95 percent / PPh3 / [Pd(dba)2] / tetrahydrofuran / 20 °C 2.1: tBuLi / tetrahydrofuran / 0.5 h / -78 °C 2.2: 62 percent / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 17 p. 4252 - 4264
反应条件
1.1: tBuLi / tetrahydrofuran / 1 h / -78 °C 1.2: ZnBr2 / tetrahydrofuran / 0.5 h / 20 °C 1.3: 95 percent / PPh3 / [Pd(dba)2] / tetrahydrofuran / 20 °C 2.1: tBuLi / tetrahydrofuran / 0.5 h / -78 °C 2.2: 62 percent / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 17 p. 4252 - 4264
反应条件
potassium permanganate in water; acetone T=50°C; 2 h;
参考文献
Dupuis, Christophe; Adiey, Kouacou; Charruault, Lise; Michelet, Veronique; Savignac, Monique; Genet, Jean-Pierre
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6523 - 6526
反应条件
potassium permanganate in sodium hydroxide; water; tert-butyl alcohol
参考文献
Eaddy, III; John F.
Patent: US4578522 A1, 1986 ;
反应条件
in water; toluene; tert-butyl alcohol
参考文献
Shintaku, Tetsuya; Tanaka, Masahide; Shiratani, Hiroshi; Itaya, Nobushige
Patent: US2001/20110 A1, 2001 ;
