2-苯甲酰基-1-氰基-1,2-二氢异喹啉合成路线 （共 61 条）
反应条件
1: aqueous H2SO4
2: ethanolic H2SO4
3: sodium ethylate; toluene / und anschliessend mit wss. Salzsaeure
View Scheme
参考文献
Padbury; Lindwall
Journal of the American Chemical Society, 1945 , vol. 67, p. 1268
反应条件
1: 83 percent / dimethylformamide / 3.5 h / 0 °C
2: 65 percent / KOH
View Scheme
参考文献
Reimann; Hoglmuller
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 487 - 495
参考文献
Merck Patent Gesellschaft mit Beschraenkter Haftung
Patent: US4122180 A1, 1978 ;
反应条件
nickel; ethyl acetate
T=90 - 110°C; P=102971 - 117681 Torr; Hydrogenation;
参考文献
Leonard; Leubner
Journal of the American Chemical Society, 1949 , vol. 71, p. 3405,3407
反应条件
T=90 - 110°C; P=102971 - 117681 Torr; Hydrogenation;
参考文献
Rupe; Frey
Helvetica Chimica Acta, 1939 , vol. 22, p. 673,679
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in acetonitrile
0.0833333 h; ultrasound sonication;
参考文献
Ezquerra, Jesus; Alvarez-Builla, Julio
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 917 - 925
反应条件
1,4-dioxane; diethyl ether
T=-10°C; und anschliessend mit aether.4-Chlor-benzaldehyd-Loesung;
参考文献
Walters et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 1177,1181
反应条件
(i) NaH, DMF, (ii) NaBH4, EtOH, (iii) aq. KOH, (iv) /BRN= 1098367/, Et3N, CH2Cl2; Multistep reaction;
参考文献
Neumeyer; Boyce
Journal of Organic Chemistry, 1973 , vol. 38, # 13 p. 2291 - 2301
反应条件
1,4-dioxane; diethyl ether
Anschliessend Behandeln mit Veratrumaldehyd;
参考文献
Popp; McEwen
Journal of the American Chemical Society, 1957 , vol. 79, p. 3773,3775
反应条件
sodium hydroxide; oxygen; benzyltriethylammonium hydroxide in water; benzene
1.5 h; Ambient temperature;
参考文献
Rozwadowska, Maria; Brozda, Danuta
Canadian Journal of Chemistry, 1980 , vol. 58, p. 1239 - 1242
