1-乙烯基-6-氟-7-(3-甲基氨基吡咯烷-1-基)-4-氧代-1,8-萘啶-3-羧酸合成路线 （共 4 条）
反应条件
sodium hydroxide in ethanol
Heating;
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
反应条件
1: POCl3 / 0.1 h / 115 °C
2: CHCl3 / 0.5 h / 40 °C
3: 73 percent / Et3N / ethanol / Heating
4: 87 percent / aq. NaOH / ethanol / Heating
View Scheme
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
反应条件
1: 73 percent / Et3N / ethanol / Heating
2: 87 percent / aq. NaOH / ethanol / Heating
View Scheme
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
反应条件
1: 1.) KOH, 2.) aq. NaOH / 1.) EtOH, reflux, 2 h, 2.) EtOH, 120 deg C, 18 h
2: POCl3 / 0.1 h / 115 °C
3: CHCl3 / 0.5 h / 40 °C
4: 73 percent / Et3N / ethanol / Heating
5: 87 percent / aq. NaOH / ethanol / Heating
View Scheme
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
