7-(3-氨基吡咯烷-1-基)-6-氟-1-(2-氟乙基)-4-氧代-1,8-萘啶-3-羧酸合成路线 （共 4 条）
反应条件
hydrogenchloride
Heating;
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
反应条件
1: 1.) K2CO3 / 1.) DMF, 65 deg C, 1 h, 2.) DMF, 100 to 105 deg C, 1.5 h
2: 74 percent / m-chloroperbenzoic acid / CHCl3 / 2 h / Ambient temperature
3: 73 percent / Et3N / ethanol / Heating
4: 73 percent / aq. HCl / Heating
View Scheme
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
反应条件
1: 74 percent / m-chloroperbenzoic acid / CHCl3 / 2 h / Ambient temperature
2: 73 percent / Et3N / ethanol / Heating
3: 73 percent / aq. HCl / Heating
View Scheme
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
反应条件
1: 73 percent / Et3N / ethanol / Heating
2: 73 percent / aq. HCl / Heating
View Scheme
参考文献
Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548
