5-氰基-2-羟基苯甲酸甲酯合成路线 （共 7 条）
反应条件
1: in DMF (N,N-dimethyl-formamide) 7 h; Heating / reflux; 2: With hydrogenchloride; anhydrous iron chloride in DMF (N,N-dimethyl-formamide); water T=80°C; 0.5 h;
参考文献
AstraZeneca AB
Patent: US2004/229900 A1, 2004 ;
Location in patent: Page 17 ;
反应条件
in DMF (N,N-dimethyl-formamide) T=140°C; 20 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2005/11685 A1, 2005 ;
Location in patent: Page/Page column 42 ;
WO 2005/011685 A1
反应条件
hydrogenchloride; FeCl3; CuCN in N,N-dimethyl-formamide
参考文献
AstraZeneca AB
Patent: US6291475 B1, 2001 ;
US 6291475 B1
反应条件
palladium diacetate; triphenylphosphine on polystyrene in N,N-dimethyl-formamide T=140°C; 0.5 h; Irradiationmicrowave;
参考文献
Srivastava, Rajiv R.; Collibee, Scott E.
Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8895 - 8897
反应条件
ethylenediamine in water
参考文献
The Green Cross Corporation
Patent: US5635527 A1, 1997 ;
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide
T=20°C; 66 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/113289 A1, 2007 ;
Location in patent: Page/Page column 36 ;
WO 2007/113289 A1
反应条件
potassium carbonate in acetone
T=65°C;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2007/77435 A1, 2007 ;
Location in patent: Page/Page column 205-206 ;
WO 2007/077435 A1
