2-[4-(苯甲酰基氧基)苯基]苯并[b]噻吩-6-醇 6-苯甲酸酯合成路线 （共 6 条）
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
Ambient temperature;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C
2: 71 percent / pyridine hydrochloride / 6 h / 220 °C
3: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 1.5 h
2: water, methanesulfonic acid / ethanol / 72 h / Heating
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
