1-H-吡唑-3-硼酸频哪酯合成路线 （共 5 条）
反应条件
caesium carbonate in acetonitrile T=20°C; 70 h;
参考文献
US2012/316166 A1, ;
Page/Page column 71 ;
反应条件
caesium carbonate; tetrakis (triphenylphosphine) palladium (0) in 1,4-dioxane; water T=150°C; 0.833333 h; Sealed tubeMicrowave irradiation;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; Chau, Ryan W.; Cullis, Courtney A.; Duffey, Matthew O.; Gipson, Krista E.; Hu, Yongbo; Li, Gang; Sintchak, Michael D.; Vos, Tricia J.
Patent: US2013/165464 A1, 2013 ;
Location in patent: Paragraph 0974 ;
反应条件
1: 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; 2: trimethylsilyl ethoxymethyl chloride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; BURGESS, Laurence, E.; GRONEBERG, Robert, D.; HARVEY, Darren, M.; HUANG, Lily; KERCHER, Timothy; KRASER, Christopher, F.; LAIRD, Ellen; TARLTON, Eugene; ZHAO, Qian
Patent: WO2011/130146 A1, 2011 ;
Location in patent: Page/Page column 161-162 ;
WO 2011/130146 A1
反应条件
caesium carbonate in acetonitrile T=20°C; 70 h;
参考文献
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Patent: US2012/316166 A1, 2012 ;
Location in patent: Page/Page column 71 ;
反应条件
1: 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 1 h; 2: 2-iodo-propane in N,N-dimethyl-formamide T=0 - 20°C; 16 h;
参考文献
WO2008/122784 A1, ;
Page/Page column 51-52 ;
WO 2008/122784 A1
