3-叠氮基-2,3-二脱氧尿苷合成路线 （共 23 条）
反应条件
air; bromine; triethylamine 1.) H2O, THF, room temperature, 3.) room temperature; Yield given. Multistep reaction;
参考文献
Lin, Tai-Shun; Guo, Ji-Yu; Schinazi, Raymond F.; Chu, Chung K.; Xiang, Jia-Ning; Prusoff, Willian H.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 336 - 340
反应条件
1: 16 percent / acetic acid / Ambient temperature 2: 1.) dithiothreitol, 0.1 M EDTA, 2.) aq. NaOH / 1.) pH 7.8, MeOH, 2.) MeOH, room temperature View Scheme
参考文献
Lin, Tai-Shun; Guo, Ji-Yu; Schinazi, Raymond F.; Chu, Chung K.; Xiang, Jia-Ning; Prusoff, Willian H.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 336 - 340
反应条件
in acetic acid Ambient temperature;
参考文献
Lin, Tai-Shun; Guo, Ji-Yu; Schinazi, Raymond F.; Chu, Chung K.; Xiang, Jia-Ning; Prusoff, Willian H.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 336 - 340
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 2 h;
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
1: pyridine / 24 h / 4 °C 2: thionyl chloride / CHCl3; dimethylformamide / 6 h / Heating 3: 31 percent / NH3 / methanol / 144 h / Ambient temperature 4: 65 percent / H2 / 10percent Pd/C / methanol / 2 h / 2585.7 Torr View Scheme
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
acetic acid
T=55°C; 4 h;
参考文献
Zaitseva; Kvasyuk; Vaaks; Barai; Bokut; Zinchenko; Mikhailopulo
Nucleosides and Nucleotides, 1994 , vol. 13, # 1-3 p. 819 - 834
反应条件
lithium azide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=90°C; 18 h;
参考文献
Krenitsky; Freeman; Shaver; Beacham III; Hurlbert; Cohn; Elwell; Selway
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 891 - 895
反应条件
lithium azide in N,N-dimethyl-formamide
T=105 - 110°C; 24 h;
参考文献
Sehgal, Raj K.; Turcotte, Joseph G.
Journal of Chemical Research, Miniprint, 1998 , # 1 p. 301 - 326
反应条件
1: 88 percent / 1N NaOH / ethanol; H2O / 4 h / Heating
2: 91 percent / pyridine / 24 h / Ambient temperature
3: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C
4: 70 percent / 80percent acetic acid / 0.33 h / Heating
View Scheme
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
1: 44 percent / dimethylformamide / 3 h / 85 - 90 °C
2: LiN3 / dimethylformamide / 24 h / 105 - 110 °C
View Scheme
参考文献
Sehgal, Raj K.; Turcotte, Joseph G.
Journal of Chemical Research, Miniprint, 1998 , # 1 p. 301 - 326
