3-叠氮基-2,3-二脱氧尿苷合成路线 （共 23 条）
反应条件
1: 93 percent / pyridine / 24 h / 4 °C
2: 88 percent / 1N NaOH / ethanol; H2O / 4 h / Heating
3: 91 percent / pyridine / 24 h / Ambient temperature
4: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C
5: 70 percent / 80percent acetic acid / 0.33 h / Heating
View Scheme
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
1: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C
2: 70 percent / 80percent acetic acid / 0.33 h / Heating
View Scheme
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
1: 91 percent / pyridine / 24 h / Ambient temperature
2: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C
3: 70 percent / 80percent acetic acid / 0.33 h / Heating
View Scheme
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
1: 80percent AcOH / 0.33 h / Heating
2: 26 percent / lithium azide / hexamethylphosphoric acid triamide / 18 h / 90 °C
View Scheme
参考文献
Krenitsky; Freeman; Shaver; Beacham III; Hurlbert; Cohn; Elwell; Selway
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 891 - 895
反应条件
1: 76 percent / LiN3, p-toluenesulfonic acid / hexamethylphosphoric acid triamide / 3 h / 100 °C
2: 78 percent / acetic acid / 0.5 h / 100 °C
View Scheme
参考文献
Colla; Herdewijn; De Clercq; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 4 p. 295 - 301
反应条件
1: imidazole / dimethylformamide
2: LiN3 / tetrahydrofuran; acetic acid; H2O
3: 77 percent / DIBAL / CH2Cl2 / -78 °C
4: pyridine
5: 55 percent / trimethylsilyl triflate / 1,2-dichloro-ethane
6: n-tetrabutylammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Chu, Chung K.; Beach, J. Warren; Ullas, Giliyar V.; Kosugi, Yoshiyuki
Tetrahedron Letters, 1988 , vol. 29, # 42 p. 5349 - 5352
反应条件
1: 90 percent / dil. HCl
2: imidazole / dimethylformamide
3: LiN3 / tetrahydrofuran; acetic acid; H2O
4: 77 percent / DIBAL / CH2Cl2 / -78 °C
5: pyridine
6: 55 percent / trimethylsilyl triflate / 1,2-dichloro-ethane
7: n-tetrabutylammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Chu, Chung K.; Beach, J. Warren; Ullas, Giliyar V.; Kosugi, Yoshiyuki
Tetrahedron Letters, 1988 , vol. 29, # 42 p. 5349 - 5352
反应条件
1: LiN3 / tetrahydrofuran; acetic acid; H2O
2: 77 percent / DIBAL / CH2Cl2 / -78 °C
3: pyridine
4: 55 percent / trimethylsilyl triflate / 1,2-dichloro-ethane
5: n-tetrabutylammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Chu, Chung K.; Beach, J. Warren; Ullas, Giliyar V.; Kosugi, Yoshiyuki
Tetrahedron Letters, 1988 , vol. 29, # 42 p. 5349 - 5352
反应条件
1: 77 percent / DIBAL / CH2Cl2 / -78 °C
2: pyridine
3: 55 percent / trimethylsilyl triflate / 1,2-dichloro-ethane
4: n-tetrabutylammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Chu, Chung K.; Beach, J. Warren; Ullas, Giliyar V.; Kosugi, Yoshiyuki
Tetrahedron Letters, 1988 , vol. 29, # 42 p. 5349 - 5352
反应条件
1: 55 percent / trimethylsilyl triflate / 1,2-dichloro-ethane
2: n-tetrabutylammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Chu, Chung K.; Beach, J. Warren; Ullas, Giliyar V.; Kosugi, Yoshiyuki
Tetrahedron Letters, 1988 , vol. 29, # 42 p. 5349 - 5352
