3’-氨基-2’,3’-二脱氧尿苷合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 2 h;
参考文献
Lin; Mancini
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 544 - 548
反应条件
1: 85 percent / aq. acetic acid / 4 h / 55 °C 2: 67 percent / Ph3P, pyridine, aq. NH3 View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 819 - 834
反应条件
1: 88 percent / 1N NaOH / ethanol; H2O / 4 h / Heating 2: 91 percent / pyridine / 24 h / Ambient temperature 3: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C 4: 70 percent / 80percent acetic acid / 0.33 h / Heating 5: 86 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 4 p. 544 - 548
反应条件
1: 93 percent / pyridine / 24 h / 4 °C 2: 88 percent / 1N NaOH / ethanol; H2O / 4 h / Heating 3: 91 percent / pyridine / 24 h / Ambient temperature 4: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C 5: 70 percent / 80percent acetic acid / 0.33 h / Heating 6: 86 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 4 p. 544 - 548
反应条件
1: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C 2: 70 percent / 80percent acetic acid / 0.33 h / Heating 3: 86 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 4 p. 544 - 548
反应条件
1: 91 percent / pyridine / 24 h / Ambient temperature 2: 86 percent / LiN3 / dimethylformamide / 2 h / 85 °C 3: 70 percent / 80percent acetic acid / 0.33 h / Heating 4: 86 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 4 p. 544 - 548
反应条件
methylamine in ethanol 2 h; Heating;
参考文献
Motawia; Pedersen; Suwinski; Nielsen
Archiv der Pharmazie, 1990 , vol. 323, # 12 p. 949 - 953
反应条件
1: 76 percent / LiN3, p-toluenesulfonic acid / hexamethylphosphoric acid triamide / 3 h / 100 °C 2: 78 percent / acetic acid / 0.5 h / 100 °C 3: 1.) H2 / 1.) 10 percent Pd/C / 1.) EtOH-H2O, 2h, 40 psi 4: 59 percent / H2O View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 20, # 4 p. 295 - 301
反应条件
1: 17 percent / trimethylsilyl triflate / acetonitrile / 2 h / -30 °C 2: 70 percent / CH3NH2 / ethanol / 2 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 323, # 12 p. 949 - 953
参考文献
Colla; Herdewijn; De Clercq; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 4 p. 295 - 301
