1-苄氧羰基-3-甲基哌嗪合成路线 （共 9 条）
反应条件
in butan-1-ol T=0 - 8°C; 2 h; Product distribution / selectivity;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 16; 17 ;
反应条件
1: in butan-1-ol T=0 - 20°C; 14 h; 2: With sodium hydroxide in water; toluene pH=11.2; 3: With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 16; 20-21 ;
反应条件
in butan-1-ol T=0 - 25°C; 14 h; Product distribution / selectivity;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 18-19 ;
反应条件
in tetrahydrofuran 1.) 0 deg C, 24 h, 2.) r.t., 12 h;
参考文献
Kondo, Kazuhiro; Sekimoto, Erika; Nakao, Junko; Murakami, Yasuoki
Tetrahedron, 2000 , vol. 56, # 32 p. 5843 - 5856
反应条件
T=23°C; Acylation; 24 h;
参考文献
Kondo, Kazuhiro; Sekimoto, Erika; Nakao, Junko; Murakami, Yasuoki
Tetrahedron, 2000 , vol. 56, # 32 p. 5843 - 5856
反应条件
1: in butan-1-ol T=0 - 8°C; 2 h; 2: With hydrogenchloride in water; toluene T=0°C; pH=1.0; 0.5 h; 3: With sodium hydroxide in water; toluene T=60 - 170°C; pH=11.8; 0.5 h; Product distribution / selectivity;
参考文献
EP1548010 A1, ;
Page/Page column 21 ;
反应条件
1: (S)-(+)-2-Methylpiperazine in water T=15 - 85°C; 7 h; 2: With calcium hydroxide powder in water T=70 - 82°C; 3 h; 3: benzyl chloroformate With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
参考文献
EP1548010 A1, ;
Page/Page column 22-23 ;
反应条件
1: 90 percent / pyridine / 1 h / Ambient temperature 2: 91 percent / tetrahydrofuran / 1.) 0 deg C, 24 h, 2.) r.t., 12 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 18 p. 2973 - 2974
反应条件
1: 1.) H2O, NaHCO3, 2.) Et3N / 2.) CH2Cl2, RT, overnight
2: 25percent HBr / acetic acid
View Scheme
参考文献
Morikawa; Sone; Asano
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
