2-氯-4-氟-5-硝基苯酚合成路线 （共 16 条）
反应条件
1: With sodium hydroxide; water 4 h; 2: With hydrogenchloride in water
参考文献
US2008/90856 A1, ;
Page/Page column 38 ;
US 20080090856 A1
反应条件
water; sodium hydrogencarbonate in methanol T=20°C; 16 h;
参考文献
WO2008/133753 A2, ;
Page/Page column 88 ;
反应条件
sodium hydroxide; nitric acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; sulfuric acid
反应条件
1: sodium hydroxide / water / -10 °C 2: sulfuric acid; 2-methyl-5-nitrophenol / 0.5 h / 0 °C 3: sodium hydroxide; water / 4 h / |Reflux View Scheme
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 4 h;
参考文献
LACKEY, Karen Elizabeth
Patent: US2008/234267 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
potassium carbonate in diethyl ether; acetone
参考文献
ChemoCentryx, Inc.
Patent: US2004/162282 A1, 2004 ;
US 20040162282 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=2585.81 Torr; 12 h;
参考文献
US2008/90856 A1, ;
Page/Page column 38 ;
US 20080090856 A1
参考文献
Ando, Iwao; Ohtsuka, Toshikazu; Miki, Nobuo; Takahashi, Toshio; Hayase, Yoshio; Hayashi, Yoshiyuki
Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 2001 - 2004
反应条件
2: H2 3: dicyclohexylimide (DCC) / acetone / 40 °C View Scheme
参考文献
Ando, Iwao; Ohtsuka, Toshikazu; Miki, Nobuo; Takahashi, Toshio; Hayase, Yoshio; Hayashi, Yoshiyuki
Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 2001 - 2004
反应条件
2: H2 3: acetone / 40 °C View Scheme
参考文献
Ando, Iwao; Ohtsuka, Toshikazu; Miki, Nobuo; Takahashi, Toshio; Hayase, Yoshio; Hayashi, Yoshiyuki
Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 2001 - 2004
