2-甲基-2-丙基(2-氟-6-甲酰基苯基)氨基甲酸酯合成路线 （共 5 条）
反应条件
1.1: tert-butyllithium / tetrahydrofuran; pentane / -25 °C 1.2: 66 percent / tetrahydrofuran; pentane 2.1: 37 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 80 °C View Scheme
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
1: (2-fluoro-phenyl)-carbamic acid tert-butyl ester With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; pentane
T=-78 - 20°C;
参考文献
Degnan, Andrew P.; Han, Xiaojun; Dubowchik, Gene M.; Macor, John E.; Mercer, Stephen E.
Patent: US2005/215576 A1, 2005 ;
Location in patent: Page/Page column 46 ;
US 20050215576 A1
反应条件
1.1: 85 percent / toluene / Heating
2.1: tert-butyllithium / tetrahydrofuran; pentane / -50 °C
2.2: 72 percent / tetrahydrofuran; pentane / -50 - 25 °C
View Scheme
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
1.1: 85 percent / toluene / Heating
2.1: tert-butyllithium / tetrahydrofuran; pentane / -50 °C
2.2: 72 percent / tetrahydrofuran; pentane / -50 - 25 °C
View Scheme
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
hydrogenchloride in 1,4-dioxane
T=60°C; 3 h;
参考文献
Chelucci, Giorgio; Orru, Gianmauro
Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3493 - 3496
