1-[3-[2-[4-(2-甲基-5-喹啉基)-1-哌嗪基]乙基]苯基]-2-咪唑烷酮合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=20 - 75°C; 4.5 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/14552 A1, 2005 ;
Location in patent: Page/Page column 64 ;
WO 2005/014552 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Cimarosti, Zadeo; Giubellina, Nicola; Stabile, Paolo; Laval, Gilles; Tinazzi, Francesco; Maton, William; Pachera, Roberta; Russo, Paola; Moretti, Ramona; Rossi, Sara; Cooke, Jason W. B.; Westerduin, Pieter
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1287 - 1296
反应条件
1: 2-picoline / anhydrous propionitrile / 0.5 h / 40 °C / Inert atmosphere; Large scale reaction
2: N-ethyl-N,N-diisopropylamine / anhydrous propionitrile / 10 h / 94 °C / Reflux; Large scale reaction
View Scheme
参考文献
Cimarosti, Zadeo; Giubellina, Nicola; Stabile, Paolo; Laval, Gilles; Tinazzi, Francesco; Maton, William; Pachera, Roberta; Russo, Paola; Moretti, Ramona; Rossi, Sara; Cooke, Jason W. B.; Westerduin, Pieter
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1287 - 1296
