4-[[1-[(4-氟苯基)甲基]-1H-苯并咪唑-2-基]氨基]哌啶-1-甲酸乙酯合成路线 （共 18 条）
反应条件
1: 84 percent / phosphoryl chloride / 5.5 h / Heating 2: 56 percent / 5 h / 125 °C View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
反应条件
1: 1.) NaH / 1.) DMF, 60 deh C, 1 h, 2.) DMF, 60 deg C, 5.5 h 2: 84 percent / phosphoryl chloride / 5.5 h / Heating 3: 56 percent / 5 h / 125 °C View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3323 - 3329
反应条件
lutidine; cesium fluoride in various solvent(s) T=120°C; Substitution; 3 h; Product distribution; Further Variations:ReagentsSolventsTemperaturespH-values;
参考文献
Tetrahedron Letters, , vol. 40, # 38 p. 6875 - 6879
反应条件
1: 95 percent / aq. HBr / 1 h / Heating 2: 1.) NaH, KI / 1.) DMF, 70 deg C, 10 h, 2.) DMF, 70 deg C, 12 h View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating 2: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 3: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating
2: 23 percent / butan-1-ol
View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
hydrogen bromide
1 h; Heating;
参考文献
De Parrodi, Cecilia Anaya; Quintero-Cortes, Leticia; Sandoval-Ramirez, Jesus
Synthetic Communications, 1996 , vol. 26, # 17 p. 3323 - 3329
反应条件
hydrogen bromide
18 h; Heating;
参考文献
Martin, Rainer E.; Green, Luke G.; Guba, Wolfgang; Kratochwil, Nicole; Christ, Andreas
Journal of Medicinal Chemistry, 2007 , vol. 50, # 25 p. 6291 - 6294
