(2S,4R)-BOC-Γ-甲磺酰基氧甲基脯氨酸甲酯合成路线 （共 30 条）
反应条件
1: 85 percent / N-methylmorpholine; 4-(dimethylamino)pyridine / dimethylformamide / 13 h / 55 °C 2: 72 percent / pyridine / 13 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 14 p. 5186 - 5190
反应条件
1: 80 percent / HCl gas / 2 h / Heating 2: 85 percent / N-methylmorpholine; 4-(dimethylamino)pyridine / dimethylformamide / 13 h / 55 °C 3: 72 percent / pyridine / 13 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 14 p. 5186 - 5190
反应条件
1: methanol; diethyl ether 2: triethylamine / dichloromethane / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 1 p. 251 - 259
反应条件
di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine in tetrahydrofuran T=70°C; Mitsunobu Displacement; 15 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3140 - 3144
反应条件
in dimethyl sulfoxide T=55°C; 72 h; Inert atmosphere;
参考文献
US2013/115194 A1, ;
Paragraph 0412 ;
反应条件
sodium hydroxide in 1,4-dioxane T=0 - 5°C; 2.5 h;
参考文献
Lange, Udo E.W.; Baucke, Dorit; Hornberger, Wilfried; Mack, Helmut; Seitz, Werner; Hoeffken, H. Wolfgang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2648 - 2653
反应条件
1: With sodium tetrahydroborate; diphenyl diselenide in methanol 11 h; Heating; 2: With pyridine; dihydrogen peroxide in dichloromethane; water T=20°C; 2 h;
参考文献
Qiu, Xiao-Long; Qing, Feng-Ling
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3826 - 3837
反应条件
cesium fluoride in tert-butyl alcohol T=100°C; 7 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
1.1: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere 2.1: sodium hydroxide; water / methanol / 20 °C 2.2: pH 2 View Scheme
参考文献
LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang
Patent: US2013/115194 A1, 2013 ;
反应条件
1: 6.74 g / NaN3 / dimethylformamide / 60 °C 2: 2N NaOH / dioxane / 1 h / 25 °C View Scheme
参考文献
ENSEMBLE THERAPEUTICS; BRISTOL-MYERS SQUIBB COMPANY; SEIGAL, Benjamin, Adam; TERRETT, Nicholas; CARTER, Percy, H.; BORZILLERI, Robert, M.; ZHANG, Yong; MILLER, Michael, M.
Patent: WO2013/71035 A1, 2013 ;
