3-氟-1-甲基哌啶-4-酮合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h; Inert atmosphere;
参考文献
Liu, Jack; Chan, Johann; Bryant, Craig M.; Duspara, Petar A.; Lee, Ernest E.; Powell, David; Yang, Hua; Liu, Ziping; Walpole, Chris; Roberts, Edward; Batey, Robert A.
Tetrahedron Letters, 2012 , vol. 53, # 24 p. 2971 - 2975
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h;
参考文献
GLAXOSMITHKLINE LLC; ADAMS, Nicholas, David; CHAUDHARI, Amita, M.; KIESOW, Terence, John; McSHERRY, Allison, K.; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; REIF, Alexander, Joseph; RIDGERS, Lance, Howard
Patent: WO2014/8223 A2, 2014 ;
Location in patent: Page/Page column 110 ;
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
WO2006/113471 A2, ;
Page/Page column 27; 56 ;
WO 2006/113471 A2
反应条件
sulfuric acid; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile T=50°C; 24 h;
参考文献
Liu, Jack; Chan, Johann; Bryant, Craig M.; Duspara, Petar A.; Lee, Ernest E.; Powell, David; Yang, Hua; Liu, Ziping; Walpole, Chris; Roberts, Edward; Batey, Robert A.
Tetrahedron Letters, 2012 , vol. 53, # 24 p. 2971 - 2975
