2,4-二哌啶酮-1-甲酸叔丁酯合成路线 （共 15 条）
反应条件
in 1,4-dioxane 2 h; Reflux;
参考文献
US2010/4239 A1, ;
Page/Page column 99 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere 2: ethyl acetate / 3 h / Inert atmosphere; Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 39 p. 5036 - 5038
反应条件
1: sodium hydroxide / 3 h / 20 °C 2: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C 3: ethyl acetate / 20 h / 20 - 105 °C / Inert atmosphere View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 25°C; 5 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: potassium hydroxide / water; ethanol / 90 °C / |Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: 4-methyl-morpholine / ethylene glycol dimethyl ether / |Inert atmosphere 2: sodium tetrahydroborate / water / |Inert atmosphere 3: triethylamine / |Inert atmosphere 4: dimethyl sulfoxide / |Inert atmosphere 5: potassium hydroxide / water; ethanol / 90 °C / |Inert atmosphere 6: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: sodium tetrahydroborate / water / |Inert atmosphere 2: triethylamine / |Inert atmosphere 3: dimethyl sulfoxide / |Inert atmosphere 4: potassium hydroxide / water; ethanol / 90 °C / |Inert atmosphere 5: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: triethylamine / |Inert atmosphere 2: dimethyl sulfoxide / |Inert atmosphere 3: potassium hydroxide / water; ethanol / 90 °C / |Inert atmosphere 4: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: dimethyl sulfoxide / |Inert atmosphere 2: potassium hydroxide / water; ethanol / 90 °C / |Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h; Product distribution / selectivity;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.
Patent: WO2008/104475 A1, 2008 ;
Location in patent: Page/Page column 22 ;
WO 2008/104475 A1
