4-(哌啶-4-基氧基)哌啶-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide in ethanol
T=20°C; 14 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/45313 A2, 2009 ;
Location in patent: Page/Page column 43-44 ;
WO 2009/045313 A2
反应条件
1: With lithium borohydride in tetrahydrofuran; methanol
T=30°C; 2 h;
2: With formic acid; ammonium formate; palladium 10 on activated carbon in tetrahydrofuran; methanol
48 h;
3: With hydrogen; sodium hydrogencarbonate; acetic acid; palladium 10 on activated carbon
Product distribution / selectivity; more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/14571 A1, 2005 ;
Location in patent: Page/Page column 18-19 ;
WO 2005/014571 A1
反应条件
palladium 10 on activated carbon; ammonium formate in methanol
T=55°C; 1.5 h;
参考文献
Bailey, James M.; Bruton, Gordon; Huxley, Anthony; Johnstone, Vicky; Milner, Peter H.; Orlek, Barry S.; Stemp, Geoffrey
Synlett, 2009 , # 7 p. 1051 - 1054
反应条件
1: 67 percent / triphenyl phosphine; DIAD / tetrahydrofuran / 14 h / 55 °C
2: 60 percent / p-toluenesulfonic acid monohydrate; H2 / PtO2 / ethanol / 14 h / 20 °C
View Scheme
参考文献
Chao, Jianhua; Israiel, Mariam; Zheng, Junying; Aki, Cynthia
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 791 - 794
反应条件
1: 67 percent / triphenyl phosphine; DIAD / tetrahydrofuran / 14 h / 55 °C
2: 60 percent / p-toluenesulfonic acid monohydrate; H2 / PtO2 / ethanol / 14 h / 20 °C
View Scheme
参考文献
Chao, Jianhua; Israiel, Mariam; Zheng, Junying; Aki, Cynthia
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 791 - 794
