5-溴-吡啶-2-羧酸二甲酰胺合成路线 （共 3 条）
反应条件
1: 5-bromo-2-pyridinecarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 2 h;
2: dimethyl amine With N-ethyl-N,N-diisopropylamine in tetrahydrofuran; dichloromethane
T=20°C; 3 h;
参考文献
INCYTE CORPORATION
Patent: US2008/318991 A1, 2008 ;
Location in patent: Page/Page column 10 ;
US 20080318991 A1
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide
T=20°C; 40 h;
参考文献
ELI LILLY AND COMPANY; BLEISCH, Thomas, John; COATES, David, Andrew; HUGHES, Norman, Earle; JONES, Scott, Alan; NORMAN, Bryan, Hurst
Patent: WO2013/66640 A1, 2013 ;
Location in patent: Page/Page column 21; 22 ;
反应条件
1: hydrogenchloride / water / |Reflux
2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 40 h / 20 °C
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参考文献
ELI LILLY AND COMPANY; BLEISCH, Thomas, John; COATES, David, Andrew; HUGHES, Norman, Earle; JONES, Scott, Alan; NORMAN, Bryan, Hurst
Patent: WO2013/66640 A1, 2013 ;
