N-甲基-5-溴吡啶甲酰胺合成路线 （共 7 条）
反应条件
1: 5-bromo-2-pyridinecarboxylic acid With thionyl chloride in toluene 16 h; Reflux; 2: N-methylamine hydrochloride With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 76-77 ;
WO 2009/135842 A1
反应条件
in tetrahydrofuran T=20°C;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng
Patent: WO2014/32498 A1, 2014 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=18 - 25°C; 48 h;
参考文献
WO2013/91096 A1, ;
Page/Page column 78 ;
反应条件
in tetrahydrofuran T=50°C; 5 h;
参考文献
WO2012/162635 A1, ;
Page/Page column 70-71 ;
WO 2012/162635 A1
反应条件
1: triethylamine / dichloromethane / 3 h / 20 °C 2: tetrahydrofuran / 5 h / 50 °C View Scheme
参考文献
WO2012/162635 A1, ;
WO 2012/162635 A1
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=110°C; Suzuki Coupling; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng
Patent: WO2010/8847 A2, 2010 ;
Location in patent: Page/Page column 125-126 ;
反应条件
in tetrahydrofuran T=-78°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STURINO, Claudio; BEAULIEU, Pierre; DEROY, Patrick; DUPLESSIS, Martin; JAMES, Clint; LACOSTE, Jean-Eric; MINVILLE, Joannie; MORENCY, Louis; MORIN, Sébastien; SIMONEAU, Bruno; TREMBLAY, Martin
Patent: WO2013/91096 A1, 2013 ;
Location in patent: Page/Page column 78-79 ;
