5-(4-溴-2-氟苯基)-3-甲基-1,2,4-恶二唑合成路线 （共 2 条）
反应条件
sodium hydroxide; hydroxylamine hydrochloride; acetic acid in 1,4-dioxane
T=20 - 90°C; 3.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/40192 A1, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/040192 A1
反应条件
1: T=120°C; 2 h;
2: With sodium hydroxide; hydroxylamine hydrochloride; acetic acid in 1,4-dioxane; water
T=20 - 90°C; 3.5 h;
3: With sodium hydrogencarbonate in water
pH=9;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/14571 A1, 2005 ;
Location in patent: Page/Page column 30-31 ;
WO 2005/014571 A1
