2,4-二甲氧基-5H-吡咯并[3,2-d]嘧啶合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal
T=70°C; P=4137.2 Torr;
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Tetrahedron Letters, 1982 , vol. 23, # 46 p. 4759 - 4762
反应条件
hydrogen; T1-Raney nickel in ethanol
16 h; Ambient temperature;
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1060 - 1064
反应条件
1: dimethylformamide / 1 h / 20 °C
2: 27 percent / H2 / T1-Raney nickel / ethanol / 16 h / Ambient temperature
View Scheme
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1060 - 1064
反应条件
1: 55 percent / H2O; ethanol / 2 h / 5 °C
2: H2 / 10percent Pd/C / ethyl acetate / 1.5 h / 70 °C / 4137.2 Torr
View Scheme
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1060 - 1064
反应条件
1: 55 percent / methanol / 1.) 10 min, 2.) reflux, 2 h
2: dimethylformamide / 1 h / 20 °C
3: 27 percent / H2 / T1-Raney nickel / ethanol / 16 h / Ambient temperature
View Scheme
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1060 - 1064
反应条件
1: 73 percent / Et4NCl, Pd(PPh3)2Cl2 / tetrahydrofuran / 15 h / Heating
2: H2 / W-2 Raney Ni / methanol / 2 h
3: concd. HCl / methanol / 1.17 h / Heating
View Scheme
参考文献
Sakamoto; Satoh; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 81 - 86
反应条件
1: H2 / W-2 Raney Ni / methanol / 2 h
2: concd. HCl / methanol / 1.17 h / Heating
View Scheme
参考文献
Sakamoto; Satoh; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 81 - 86
反应条件
1: 78 percent / 57percent aq. HI / 24 h / Ambient temperature
2: 73 percent / Et4NCl, Pd(PPh3)2Cl2 / tetrahydrofuran / 15 h / Heating
3: H2 / W-2 Raney Ni / methanol / 2 h
4: concd. HCl / methanol / 1.17 h / Heating
View Scheme
参考文献
Sakamoto; Satoh; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 81 - 86
