3,5-二溴-N,N-二甲基氨基吡嗪合成路线 （共 4 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 0.25 h;
参考文献
Jiang, Biao; Yang, Cai-Guang; Xiong, Wen-Nan; Wang, Jun
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1149 - 1154
反应条件
bromine; triethylamine in tetrachloromethane Ambient temperature1.) 30 min, 2.) 2 h;
参考文献
Paudler, William W.; Jovanovic, Misa V.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1064 - 1069
反应条件
1: 3,5-Dibromo-N-methylpyrazin-2-amine With sodium hexamethyldisilazane in N,N-dimethyl-formamide 2: methyl iodide in N,N-dimethyl-formamide 0.25 h;
参考文献
WO2008/99210 A2, ;
Page/Page column 63 ;
WO 2008/099210 A2
反应条件
bromine; triethylamine in tetrachloromethane Ambient temperature1.) 30 min, 2.) 2h;
参考文献
Journal of Organic Chemistry, , vol. 48, # 7 p. 1064 - 1069
