5-溴-2-(甲基氨基)吡啶合成路线 （共 12 条）
反应条件
in ethanol T=80°C; 24 h;
参考文献
KEMIA, INC.
Patent: WO2008/89034 A2, 2008 ;
Location in patent: Page/Page column 127 ;
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=140°C; 0.666667 h; microwave;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TREU, Matthias; KARNER, Thomas; REISER, Ulrich
Patent: WO2010/12747 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 5-bromopyridin-2-yl amine With sodium hydride in N,N-dimethyl-formamide 0.5 h; Cooling with ice; 2: methyl iodide T=20°C; 24 h;
参考文献
WO2011/54841 A1, ;
Page/Page column 40 ;
反应条件
in CH3NH2; ethanol; dichloromethane
参考文献
MacDonald, James E.; Jeffrey, McKelvy F.; Wong-Staal, Flossie
Patent: US2011/117055 A1, 2011 ;
反应条件
in tetrahydrofuran T=23°C; 16 h;
参考文献
McArthur, Silvia Gatti; Goetschi, Erwin; Palmer, Wylie Solang; Wichmann, Juergen; Woltering, Thomas Johannes
Patent: US2006/217387 A1, 2006 ;
Location in patent: Page/Page column 31 ;
US 20060217387 A1
反应条件
NaH in N,N-dimethyl-formamide; mineral oil
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-78°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 2 p. 707 - 718
反应条件
1: 90 percent / acetone / 2 h / 20 °C 2: 91 percent / HCO2H; Et3N / Pt/C / acetonitrile / 5 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 16 p. 2481 - 2490
反应条件
sulfuric acid; bromine; potassium bromide
参考文献
Chemische Berichte, , vol. 61, p. 1230
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 60, p. 975
反应条件
sodium tetrahydroborate Multistep reaction;
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
