(1-甲基-1H-吡唑-3-基)甲醇合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 18 h;
参考文献
WO2014/66795 A1, ;
Paragraph 0175 ;
反应条件
1: With sodium hydride in tetrahydrofuran T=0 - 20°C; 2: With methanol; potassium hydroxide T=20°C; 24 h; 3: With hydrogenchloride; lithium aluminium tetrahydride more than 3 stages;
参考文献
WO2006/34277 A1, ;
Page/Page column 60-61 ;
WO 2006/034277 A1
反应条件
in tetrahydrofuran; chloroform
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 4 p. 961 - 982
反应条件
lithium aluminium tetrahydride in diethyl ether 0.666667 h; Heating;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
反应条件
1: 76 percent / SOCl2 / 4 h / Heating 2: LiAlH4 / diethyl ether / 0.67 h / Heating View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
反应条件
pyridinium chlorochromate
参考文献
Nag, Somnath; Nayak, Maloy; Batra, Sanjay
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 16 p. 2715 - 2723
反应条件
1: SOCl2 / 0.25 h / Heating
2: 45 percent / dimethylformamide / 2 h / Heating
3: 40 percent / EtOLi / ethanol / 2 h / Heating
View Scheme
参考文献
Perevalov, V. P.; Karim, A. K. Kh.; Andreeva, M. A.; Rumyantsev, E. G.; Stepanov, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2598 - 2605,2297 - 2303
