1: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide
5 h; Heating / reflux;
2: With methanol; potassium hydroxide; water
1 h;
3: With hydrogenchloride; potassium carbonate
more than 3 stages;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2005/105778 A2, 2005 ;
Location in patent: Page/Page column 85-86 ;
WO 2005/105778 A2