1: 93 percent / sodium borohydride, 37percent hydrochloric acid / methanol; H2O / 2 h / 0 °C 2: 85 percent / pyridine / 15 h / Ambient temperature 3: 86 percent / ferric chloride on silica gel / CHCl3 / 15 h / Ambient temperature 4: sodium periodate / methanol; H2O / 12 h / Ambient temperature 5: NaBH4 / methanol; H2O / 0.5 h / Ambient temperature 6: 91 percent / pyridine, 4-dimethylaminopyridine / 12 h / Ambient temperature 7: 82 percent / hydrogen / 10percent Pd/C / ethyl acetate / 5 h / Ambient temperature 8: 99 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -78 °C 9: zinc powder, acetic acid / tetrahydrofuran; H2O / 30 h / Ambient temperature 10: zinc chloride / CH2Cl2 / 0.17 h / Ambient temperature 11: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 12: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 13: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 14: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 15: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 91 percent / pyridine, 4-dimethylaminopyridine / 12 h / Ambient temperature 2: 82 percent / hydrogen / 10percent Pd/C / ethyl acetate / 5 h / Ambient temperature 3: 99 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -78 °C 4: zinc powder, acetic acid / tetrahydrofuran; H2O / 30 h / Ambient temperature 5: zinc chloride / CH2Cl2 / 0.17 h / Ambient temperature 6: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 7: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 8: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 9: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 10: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 67 percent / 38percent ammonia / H2O; tetrahydrofuran / 15 h / Ambient temperature 2: 93 percent / sodium borohydride, 37percent hydrochloric acid / methanol; H2O / 2 h / 0 °C 3: 85 percent / pyridine / 15 h / Ambient temperature 4: 86 percent / ferric chloride on silica gel / CHCl3 / 15 h / Ambient temperature 5: sodium periodate / methanol; H2O / 12 h / Ambient temperature 6: NaBH4 / methanol; H2O / 0.5 h / Ambient temperature 7: 91 percent / pyridine, 4-dimethylaminopyridine / 12 h / Ambient temperature 8: 82 percent / hydrogen / 10percent Pd/C / ethyl acetate / 5 h / Ambient temperature 9: 99 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -78 °C 10: zinc powder, acetic acid / tetrahydrofuran; H2O / 30 h / Ambient temperature 11: zinc chloride / CH2Cl2 / 0.17 h / Ambient temperature 12: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 13: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 14: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 15: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 16: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 82 percent / hydrogen / 10percent Pd/C / ethyl acetate / 5 h / Ambient temperature 2: 99 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -78 °C 3: zinc powder, acetic acid / tetrahydrofuran; H2O / 30 h / Ambient temperature 4: zinc chloride / CH2Cl2 / 0.17 h / Ambient temperature 5: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 6: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 7: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 8: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 9: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 86 percent / ferric chloride on silica gel / CHCl3 / 15 h / Ambient temperature 2: sodium periodate / methanol; H2O / 12 h / Ambient temperature 3: NaBH4 / methanol; H2O / 0.5 h / Ambient temperature 4: 91 percent / pyridine, 4-dimethylaminopyridine / 12 h / Ambient temperature 5: 82 percent / hydrogen / 10percent Pd/C / ethyl acetate / 5 h / Ambient temperature 6: 99 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -78 °C 7: zinc powder, acetic acid / tetrahydrofuran; H2O / 30 h / Ambient temperature 8: zinc chloride / CH2Cl2 / 0.17 h / Ambient temperature 9: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 10: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 11: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 12: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 13: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: zinc powder, acetic acid / tetrahydrofuran; H2O / 30 h / Ambient temperature 2: zinc chloride / CH2Cl2 / 0.17 h / Ambient temperature 3: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 4: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 5: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 6: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 7: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 2: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 3: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 4: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 2: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 3: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1: 81 percent / trifluoroacetic acid / CH2Cl2 / 5 h / Ambient temperature 2: 68 percent / N,N-diisopropylethylamine / acetonitrile / 3 h / 60 °C 3: 79 percent / 2.6 M Jones reagent, celite / acetone / 0.5 h / Ambient temperature 4: 88 percent / sodium hydroxide / methanol / 2 h / Ambient temperature 5: 81 percent / silver nitrate / methanol / 1 h / Ambient temperature View Scheme

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C 2.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -80 °C / |Inert atmosphere 2.2: -80 h / |Inert atmosphere 3.1: lithium borohydride; methanol / diethyl ether / 1.5 h / 0 - 20 °C / |Inert atmosphere 4.1: 2,4,6-trimethyl-pyridine / dichloromethane / 3.5 h / -20 °C / |Inert atmosphere 5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 22 h / 0 - 20 °C 6.1: selenium(IV) oxide; tert.-butylhydroperoxide / 1,2-dichloro-ethane / 3 h / 60 °C 7.1: triethylamine / dichloromethane / 0 - 20 °C / |Inert atmosphere 8.1: trifluoroacetic acid / dichloromethane / 3 h / -20 °C 9.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / |Inert atmosphere 10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C / |Inert atmosphere 11.1: potassium carbonate; methanol / 3 h / 20 °C / |Inert atmosphere 12.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / |Inert atmosphere 13.1: 2-methyl-but-2-ene; sodium dihydrogen phosphate dihydrate; sodium chlorite / water; dichloromethane; tert-butyl alcohol / 18 h / 0 °C 14.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2 h / 20 °C / |Inert atmosphere 15.1: magnesium; methanol / 3 h / -20 °C / |Inert atmosphere 16.1: caesium carbonate / acetone / 13 h / 0 °C / |Inert atmosphere; |Darkness 17.1: triethylamine; tetrakis(triphenylphosphine) palladium(0); copper(II) sulfate; sodium L-ascorbate / N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere; |Darkness 18.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C 19.1: C21H27AuNP(1+)*F6Sb(1-) / 1,2-dichloro-ethane / 1 h / 45 °C / |Inert atmosphere 19.2: 0.42 h / 0 °C / |Inert atmosphere 20.1: acetic acid / toluene / 4 h / 80 °C / |Inert atmosphere 21.1: boron trifluoride diethyl etherate; tetrachlorosilane / 1,2-dichloro-ethane / 12 h / 20 °C / |Inert atmosphere 21.2: 10 h / 60 °C / |Inert atmosphere 22.1: caesium carbonate / acetone / 3.5 h / 20 °C / |Inert atmosphere 23.1: silver nitrate; water; triethylamine / acetone / 16 h / 50 °C 24.1: water; lithium hydroxide hydrate / tetrahydrofuran / 20 °C 24.2: -78 - -30 °C View Scheme