sodium carbonate; palladium diacetate; triphenylphosphine in ethylene glycol dimethyl ether; water T=90°C; 6 h;

1: With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide; water T=100°C; 2 h; 2: With sodium hydroxide in isobutyramide; water T=60°C; 1 h; 3: With hydrogenchloride in isobutyramide; water pH=5 - 6; Product distribution / selectivity;