sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate in 1,4-dioxane; water T=90°C; Suzuki-Miyaura reaction; 1.5 h;

sodium carbonate in 1,4-dioxane; methanol; ethyl acetate

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: sodium hydroxide / water View Scheme

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: sodium hydroxide / water View Scheme

in chloroform; water; acetone

1: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 2: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme