2-氯-6-(4-氯苯基)烟腈合成路线 (共 2 条)
反应条件
1: N,N-dimethyl-formamide With bis(trichloromethyl) carbonate in 1,2-dichloro-ethane T=0 - 20°C; Vilsmeier-Haack reaction; 2: para-chloroacetophenone in 1,2-dichloro-ethane T=20 - 60°C; Vilsmeier-Haack reaction; 3: malononitrile in 1,2-dichloro-ethane T=60°C; Reflux;
参考文献
Li; Hong; Su
Organic Preparations and Procedures International, 2009 , vol. 41, # 6 p. 533 - 538
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate