1-(3-(2-甲氧基-5-硝基苯氧基)丙基)-4-甲基哌嗪合成路线 (共 3 条)
反应条件
1: hydrogen; palladium on activated charcoal / isopropyl alcohol 2: orthoformic acid triethyl ester / isopropyl alcohol 3: trichlorophosphate / sulfolane / 16 h / 80 - 105 °C View Scheme
参考文献
Withbroe, Gregory J; Seadeek, Chris; Girard, Kevin P; Guinness, Steven M; Vanderplas, Brian C; Vaidyanathan, Rajappa
Organic Process Research and Development, 2013 , vol. 17, # 3 p. 500 - 504
反应条件
sodium iodide in ethylene glycol dimethyl ether
8 h; Heating / reflux;
参考文献
Wyeth Holdings Corporation
Patent: US2005/43537 A1, 2005 ;
Location in patent: Page/Page column 3; 13-14 ;
反应条件
hydrogen; palladium 10 on activated carbon in isopropyl alcohol
5 h;
参考文献
Withbroe, Gregory J; Seadeek, Chris; Girard, Kevin P; Guinness, Steven M; Vanderplas, Brian C; Vaidyanathan, Rajappa
Organic Process Research and Development, 2013 , vol. 17, # 3 p. 500 - 504