2-(4-氯苯基)-6-氧代-1,6-二氢-4-嘧啶羧酸合成路线 (共 1 条)
反应条件
1: diethyl 2-oxosuccinate sodium salt With sodium hydroxide; water
1 h;
2: 4-chlorobenzamidine hydrochloride in water
T=70°C;
3: With hydrogenchloride in water
T=20°C; pH=1.5;
参考文献
E.I. DUPONT DE NEMOURS AND COMPANY
Patent: WO2005/63721 A1, 2005 ;
Location in patent: Page/Page column 32 ;