2-(2-羟基乙基氨基)-n-苯乙酰胺合成路线 （共 5 条）
反应条件
tributylphosphine in ethyl acetate T=0 - 40°C; 2.5 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/46107 A1, 2004 ;
Location in patent: Page 230 ;
WO 2004/046107 A1
反应条件
1: chloroacetyl chloride; aniline With potassium hydrogencarbonate in water; ethyl acetate
T=0°C; 0.666667 h;
2: ethanolamine in water; ethyl acetate
T=60°C; 2 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/46107 A1, 2004 ;
Location in patent: Page 229-230 ;
WO 2004/046107 A1
反应条件
1: isopropyl acetate, aq. potassium bicarbonate / 5 °C
2: 60 °C
View Scheme
参考文献
Weissman, Steven A.; Lewis, Stephanie; Askin, David; Volante; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 41 p. 7459 - 7462
参考文献
Weissman, Steven A.; Lewis, Stephanie; Askin, David; Volante; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 41 p. 7459 - 7462
反应条件
hydrogenchloride; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine in ethyl acetate
T=0 - 5°C;
参考文献
Weissman, Steven A.; Lewis, Stephanie; Askin, David; Volante; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 41 p. 7459 - 7462
