反应条件
1.1: 50 percent / LiCl; (i-Pr)2EtN / acetonitrile / 12 h
2.1: TFA / CH2Cl2 / 0 - 20 °C
2.2: NaCNBH3 / CH2Cl2; ethanol / 0.01 h / 20 °C
2.3: aq. NaHCO3 / CH2Cl2; ethanol / 20 °C
3.1: Et3N / CH2Cl2 / 14 h
4.1: 11 percent / H2 / PtO2 / ethanol / 12 h
5.1: 95 percent / TFA / CH2Cl2 / 1 h
6.1: 74 percent / sodium cyanoborohydride / acetonitrile; H2O / 1 h / 20 °C
View Scheme
参考文献
Tchabanenko, Kirill; Adlington, Robert M.; Cowley, Andrew R.; Baldwin, Jack E.
Organic Letters, 2005 , vol. 7, # 4 p. 585 - 588
