1: 3-bromo-benzaldehyde With NAF; triphenylphosphine in ethyl acetate T=90°C; Wittig Olefination; 0.0166667 h; Schlenk techniqueInert atmosphere; 2: trimethylsilyl-2,2-difluoro-2-(fluorosulfonyl) acetate in ethyl acetate T=90°C; 1 h; Schlenk techniqueInert atmosphere;

tris-(dibenzylideneacetone)dipalladium(0); 1,4-di(diphenylphosphino)-butane in tetrahydrofuran; diethyl ether T=45°C; Negishi coupling reaction; 24 h; chemoselective reaction;

triphenylphosphine in N,N-dimethyl-formamide Yield given;

triphenylphosphine in diethylene glycol dimethyl ether T=180°C;